Tag Archives: melanoma

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http://well.blogs.nytimes.com/2013/05/27/the-new-rules-for-sunscreen/ There is no question most skin cancers are related to sun exposure, yet even with sunscreen sales approaching $1 billion a year, skin cancer rates continue to climb. Melanoma diagnoses have risen nearly 2 percent a year since 2000 … Continue reading

The Skin Cancer Foundation – Breakthrough Melanoma Drug Approved— First in a New Class of “Targeted” Treatments | melanoma

 The US Food and Drug Administration (FDA) has approved a new drug — the first of its kind — for the treatment of inoperable or advanced metastatic (spreading) melanoma. Melanoma is the deadliest form of skin cancer. The drug, called Zelboraf, was found to delay disease progression and extend life significantly.

“For patients with advanced melanoma, Zelboraf means hope — extending life for months, and in some cases, years,” said Rex Amonette, MD, Senior Vice President of The Skin Cancer Foundation. “Zelboraf represents yet another significant recent medical advancement in the fight against this disease, which claims 8,700 American lives each year.”

Zelboraf (a.k.a. vemurafenib, or PLX 4032) is the first targeted genetic therapy for melanoma approved to date. It is approved for patients whose tumors harbor a mutation (defect) in the BRAF V600E gene, which is present in about 40-60 percent of melanomas. By inhibiting the defective BRAF gene, Zelboraf slows or halts the uncontrolled (cancerous) cell growth associated with the gene mutation.

In an early clinical trial, Zelboraf was successful in shrinking the tumors of 81 percent of patients who had the mutation, the greatest response rate a melanoma drug has ever had. In more recent trials of melanoma patients, all of whom had the mutated gene, those who received Zelboraf were 56 percent less likely to die in the study period than those who received standard chemotherapy. Average overall survival for patients receiving Zelboraf could not be determined because so many patients remained alive; in contrast, average survival for patients on chemotherapy was only 7.9 months. Patients on Zelboraf were also 74 percent less likely to see their disease advance compared with patients on chemotherapy.

Along with Zelboraf, the FDA approved the cobas 4800 BRAF V600 Mutation Test, which determines if a patient has the BRAF mutation and is eligible for the treatment. Zelboraf is taken orally, and the prescribed dose is 960 mg twice a day. The drug is marketed by Roche’s Genentech, and will be available within two weeks.

via The Skin Cancer Foundation – Breakthrough Melanoma Drug Approved— First in a New Class of “Targeted” Treatments | melanoma.

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iphone apps for skin checks With the growing number of apps on the market, what do you make of this one! iphone has a new app out on the market for giving you a skin check, it stores the images … Continue reading

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FDA Approves Melafind For Detecting Skin Cancer And Melanoma. Good news for anyone worried about skin cancer with the FDA approving Melafind, which the manufacturers describe as a groundbreaking technology for detecting melanomas. Darrell S. Rigel, MD, Clinical Professor of … Continue reading

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 Understanding the genetic basis of melanoma. An international study published today in Nature Genetics, has discovered two genetic variants that increase the risk of melanoma. Melanoma is not the most common type of skin cancer but it is one of … Continue reading

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 The Skin Cancer Foundation – California Enacts Nation’s Strictest Teen Tanning Law | Tanning. Children under the age of 18 have been banned from indoor ultraviolet (UV) tanning in California. On October 9, 2011, Governor Jerry Brown signed the bill … Continue reading

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 California Bans Indoor Tanning for Minors – NYTimes.com. California this week became the first state in the country to ban indoor tanning for anyone under 18, a move that drew praise from health organizations. About 30 other states have laws … Continue reading

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 UVA Radiation May Cause DNA Damage in Skin. Ultraviolet A radiation, which can pass through window glass and clouds, causes changes to skin cells that may lead to cancer, a new study shows. Experts once thought that UVA rays, sometimes … Continue reading

Caffeine lowers risk of skin cancer.

Caffeine Lowers Risk of Skin Cancer: Coffee-Based Sunscreen Might Work Best

ScienceDaily (Aug. 25, 2011) — There might be a time when instead of just drinking that morning cup of coffee you lather it on your skin as a way of preventing harmful sun damage or skin cancer.


A new Rutgers study strengthens the theory that caffeine guards against certain skin cancers at the molecular level by inhibiting a protein enzyme in the skin, known as ATR. Scientists believe that based on what they have learned studying mice, caffeine applied directly to the skin might help prevent damaging UV light from causing skin cancer.

Prior research indicated that mice that were fed caffeinated water and exposed to lamps that generated UVB radiation that damaged the DNA in their skin cells were able to kill off a greater percentage of their badly damaged cells and reduce the risk of cells becoming cancerous.

To read more on this article follow link: Caffeine lowers risk of skin cancer: Coffee-based sunscreen might work best.